Lafayette County, MO Real Estate Search

Lafayette County, MO Commercial Properties for Sale

Our website features the best real estate search for commercial properties available in Lafayette County, MO and surrounding areas. It is the only site you will ever need! It is easy-to-use and updated by the official REALTOR®’s database every 15 minutes. 

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Newest Lafayette County, MO Commercial Properties for Sale

$294,000
Historic 1890 Church Turned Winery – Over an Acre of Endless Potential! Looking for something truly unique with history, charm, and room to grow? Welcome to this stunning 1890 church conversion, now a multi-use space full of opportunity and original character. Set on over an acre, this former house of worship has been lovingly transformed and is ready for your vision—whether that’s a one-of-a-kind home, a trendy restaurant, a lively bar or event space, or a combo of it all! Inside, you’ll be greeted by soaring ceilings, expansive windows, and the rustic charm of woodwork that tells a story more than a century old. With wide open spaces and timeless details, this property invites you to dream big. Step outside and you’ll find an entertainer’s paradise: a spacious patio complete with a bar setup, perfect for outdoor dining, live music, private events, or your own backyard oasis. And don’t miss the 2,500 sq. ft. detached building, featuring: Garage doors for flexible access Insulated walls Walk-in fridge 3-phase electrical This versatile space could be your workshop, guesthouse, commercial kitchen, studio, or a seriously cool live-work space. Highlights: Historic 1890 church full of character Could be a one-of-a-kind home, restaurant, bar, or venue Over an acre of land with plenty of room to expand Outdoor patio with bar for entertaining or business use 2,500 sq. ft. detached building with endless possibilities Insulated, walk-in fridge, and 3-phase electrical Whether you’re dreaming of a creative residence, a business venture, or both—this property is ready to be reimagined. Make history your own—schedule a tour today!

100 S Lynn Street, Dover

Listing courtesy of Kathy Adkins of Riverview Realty.
$350,000
Exceptional mixed-use commercial opportunity in a prime Odessa location with outstanding visibility and traffic exposure. Situated between McDonald’s and Taco Bell, this versatile property offers endless possibilities for investors, entrepreneurs, developers, or owner-occupants. Approved for both commercial and residential use, the flexible floor plan features multiple private entrances, nine office spaces on the upper level, four bathrooms, a large basement for storage, and front and rear parking. The layout allows for easy division into multiple office suites, residential units, retail space, professional offices, medical use, salon services, co-working space, or a live/work concept. Large windows provide abundant natural light throughout. Whether you’re seeking an income-producing investment, business headquarters, or redevelopment opportunity, this property delivers exceptional value and potential at an attractive price point. Schedule your private showing today.

121 W US Highway 40 N/A, Odessa

Listing courtesy of Jenna Pearce of Grit Real Estate LLC.
$275,000
Attention Entrepreneurs! Commercial property in prime location with so many possibilities! This property has been operating as a service station for many years and has served this owner well for the last 43 years. He is now ready for retirement. This is an opportunity to bring your ideas to life and start your own business! The station offers a 2 mechanic bay area with a work bench & rotor tuning, etc area. Additional storage room (has plumbing for a 2nd bath if desired) including shelves & a loft right off the work area. The property had gas tanks at one time and they have been removed. Lots of possibilities for all kinds of businesses at an affordable price! Great visibility on this corner location! Additional commercial property adjoining this one currently has a rental home and could be purchased as well.

101 NW Railroad Street, Odessa

Listing courtesy of Danette Kay Iman of Heritage Realty.
$200,000
Great opportunity for professional office space in the heart of Odessa in Lafayette County. This versatile property offers a functional layout with multiple rooms that can serve as private offices, meeting spaces, or collaborative work areas, making it ideal for a variety of business uses. Major updates add peace of mind, including an AC unit that is approximately 5 years old and a roof that is also around 5 years old. The property also features convenient off-street parking for clients and staff. With strong visibility and easy access within the community, this space presents a great opportunity for businesses looking to establish or expand their presence in the area.

213 S 2nd Street, Odessa

Listing courtesy of Moxie Collums Collums of Real Broker, LLC.
$255,000
Nice HISTORIC building in the downtown district. This is the former location of Odessa Creamery. Building would be good for restaurant or many other retail tpye of businesses. Building features a lot of updates with HVAC approximately 5 years old, some windows upgraded, cabinetry upgraded. Upstairs has ample storage Prime location for your business.

209 S 2nd Street, Odessa

Listing courtesy of Peggy Ragan of United Real Estate Kansas City.
$90,000
Historic commercial opportunity in downtown Lexington. This charming, updated building offers approximately 900+ square feet and is currently occupied by a photo studio, making it a great fit for creative office, boutique retail, salon, or professional service use. The space features a welcoming reception area, spacious conference or studio room, two private offices, and a half bath. Interior updates include vinyl plank flooring, fresh paint, track and pendant lighting, and attractive wood ceilings that add warmth and character. The larger office opens to the adjoining yard and courtyard, giving the property even more flexibility and appeal. Located in the business district of historic downtown Lexington, this property is full of potential for an owner-user or investor.

206 S 12th Street, Lexington

Listing courtesy of Matt Graham of Epique Realty.
$275,000
This young building is steel clear-span with painted steel roof and siding. 50 X 80 with 10 ft. sidewalls with two 12X14 overhead doors you can drive completely through. Refer to aerial photo in supplements to visualize 8 angle parking spots along the west side of the building and large concrete apron behind the building adjoining well-traveled alley. Concrete parking in front of building also. 15X50 foot of office space with 2 baths, central air and 2 man doors. Originally built for a glass company, the concrete is in great condition, exterior appears brand new and office space was completed in last few years. High visibility location one-half block off main 4-way stop downtown.

110 W Mason Street, Odessa

Listing courtesy of Brenda Oliver of Heritage Realty.
$389,000
8000 sq.ft. building with 8 units, with utilities metered separately, each with full sized front windows, overhead door in back, separate toilets and separate utilities. (Landlord pays water and sewer on one meter.) Six units presently rented, two vacant, see rent role in supplements. Great cash flow, and the commercial market in Odessa seems to be growing with small businesses looking for a place to call home.

309 E Park Lane, Odessa

Listing courtesy of Brenda Oliver of Heritage Realty.
$399,000
Prime Medical Office Space Available in Higginsville, MO. Cockerell & McIntosh Pediatrics is proud to have served this wonderful community for a decade. Now, the fully renovated medical building they previously occupied is available for the next essential medical professional. This facility is conveniently located right in the center of the established business district, offering high visibility and easy patient access. This turnkey opportunity offers over 7,100 square feet of pristine medical office space. The facility features a thoughtful layout designed for efficiency and comfort, including multiple exam rooms, a spacious reception area, dedicated medical staff workspaces, four bathrooms, two kitchenettes, and a break room. The building provides robust infrastructure with over 800 amp combined power service and abundant storage. The charm extends to a unique, farmhouse-themed lobby and integrated play gym. This distinct feature offers exceptional versatility, making the space ideal for a pediatric practice or a unique daycare facility. Originally constructed in the late 1800s, the building has undergone a comprehensive structural renovation, including steel beam reinforcement, ensuring modern safety standards while preserving its historic appeal. This meticulously upgraded property is priced to sell.

1717 N Main Street, Higginsville

Listing courtesy of Adam Booth of Booth Company Real Estate.
$1,200,000
Rare opportunity to own building in historic town with national tenant and long term lease. Corporate guaranty and 5% rental increases each renewal period.

1030 Main Street, Lexington

Listing courtesy of Jim Dollins of RE/MAX Heritage.
$1,200,000
Great opportunity to acquire building with long term national tenant. Offers corporate guaranty with 5% rental increases each renewal. Limited competition and downtown business district provide steady daily traffic.

101 S 2nd Street, Odessa

Listing courtesy of Jim Dollins of RE/MAX Heritage.
$142,000
Bates City Industrial Park - Lot 20. Conveniently located just off I-70, this expansive industrial acreage offers a prime opportunity for industrial or commercial development. The property spans 1.26 acres, with easy highway access and visibility from I-70, ensuring high traffic exposure. Zoned for industrial use, the land is ideal for warehousing, manufacturing, and distribution.

Lot 20 N Oak Street, Bates City

Listing courtesy of Wade Fitzmaurice of Fitz Osborn Real Estate LLC.
$163,350
Bates City Industrial Park - Lot 12. Conveniently located just off I-70, this expansive industrial acreage offers a prime opportunity for industrial or commercial development. The property spans 1.39 acres, with easy highway access and visibility from I-70, ensuring high traffic exposure. Zoned for industrial use, the land is ideal for warehousing, manufacturing, and distribution.

Lot 12 N Oak Street, Bates City

Listing courtesy of Wade Fitzmaurice of Fitz Osborn Real Estate LLC.
$163,350
Bates City Industrial Park - Lot 11. Conveniently located just off I-70, this expansive industrial acreage offers a prime opportunity for industrial or commercial development. The property spans 1.39 acres, with easy highway access and visibility from I-70, ensuring high traffic exposure. Zoned for industrial use, the land is ideal for warehousing, manufacturing, and distribution.

Lot 11 N Oak Street, Bates City

Listing courtesy of Wade Fitzmaurice of Fitz Osborn Real Estate LLC.
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